PRECLINICAL STUDY: Changes in leptin, ghrelin, growth hormone and neuropeptide‐Y after an acute model of MDMA and methamphetamine exposure in rats

PRECLINICAL STUDY: Changes in leptin, ghrelin, growth

Specifically, the changes in appetite following exposure to drugs of abuse are an interesting but poorly understood phenomenon. Serum hormones such as leptin, ghrelin, growth hormone (GH), and neuropeptide-Y (NP-Y) are known to affect appetite, but have not …

Published in: Addiction Biology · 2008Authors: Firas Kobeissy · Jennifer A Jeung · Matthew W Warren · Jacqueline E Geier · Mark S …Affiliation: University of FloridaAbout: Leptin · Methamphetamine · Ghrelin · Neuropeptide Y receptor · MDMA

PRECLINICAL STUDY: Changes in leptin, ghrelin, growth

Serum hormones such as leptin, ghrelin, growth hormone (GH), and neuropeptide-Y (NP-Y) are known to affect appetite, but have not been studied extensively with drugs of abuse.

Ghrelin Alleviates MDMA-Induced Disturbance of Serum

Hepatotoxicity is one of the clinically adverse effects of ecstasy (3, 4-methylenedioxymethamphetamine; MDMA) consumption. The detoxification tissue, liver, plays a central role in maintaining circulating levels of glucose and lipid. Hypoglycemia and hypotriglyceridemia have been reported due to ecstasy abuse.

Relationship between gut and sepsis: Role of ghrelin

Jan 15, 2011 · Ghrelin and synthetic ghrelin mimetics (the growth hormone secretagogues) increase food intake and increase fat mass[18,19] by an action exerted at the level of the hypothalamus. Ghrelin and other growth hormone secretagogues activate cells in the arcuate nucleus[20,21] that include the orexigenic neuropeptide Y (NPY) neurons.

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A new study says yes, while also finding that moderate exercise is an effective mood booster.

Relationship between gut and sepsis: Role of ghrelin

Ghrelin regulates growth hormone secretion, and plays an important role in the regulation of appetite, energy balance and glucose homeostasis. It regulates gastrointestinal, cardiovascular, and immune functions, and bone physiology[6-12]. Ghrelin levels increase before meals, decrease after meals, and serve as the counterpart of leptin, which induces satiation when present at higher levels.

NYAS Publications – nyaspubs.onlinelibrary.wiley.com

Ten days after exposure, the behavioral effects of MDMA were assessed in the elevated plus‐maze (n= 6 per group). After behavioral testing, animals were sacrificed and the amygdalae were dissected and processed for HPLC determination of dopamine (DA), serotonin (5‐HT), and metabolites.

Effects of chronic methamphetamine on psychomotor and

The anorexic properties of MA are further highlighted by studies showing MA-induced changes in peripheral satiety signals, including leptin, ghrelin, and neuropeptide Y , . Changes in these satiety signals after MA use, may explain the MA-induced decrease in …

The role of ghrelin in addiction: a review | Springer for

Crowley WR, Ramoz G, Keefe KA, Torto R, Kalra SP, Hanson GR (2005) Differential effects of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats.

Ghrelin receptor antagonism attenuates cocaine- and

Kobeissy FH, Jeung JA, Warren MW, Geier JE, Gold MS (2008) Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats. Addict Biol 13:15–25 CrossRef PubMed Google Scholar

Ghrelin receptor antagonism attenuates cocaine- and

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference Gold MS. Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats.

Nutritional status of drug addicts undergoing

Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats. Addiction Biology , Vol. 13, Issue. 1, p. 15.

The Relationship Between Obesity and Drug Use

Serum hormones such as leptin, ghrelin, growth hormone (GH), and neuropeptide-Y (NP-Y) are known to affect appetite, but have [Show full abstract] not been studied extensively with drugs of …

Ghrelin receptor antagonism attenuates cocaine – DeepDyve

Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats Kobeissy, FH; Jeung, JA; Warren, MW; Geier, JE; Gold, MS Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Published in: Psychopharmacology · 2010Authors: Elisabeth Jerlhag · Emil Egecioglu · Suzanne L Dickson · Jorgen A EngelAffiliation: University of GothenburgAbout: Ghrelin · Growth hormone secretagogue receptor · Catecholamine · Drug · Genetics